Masa Tsuchiya

Genomic Maxwell's Demon Control of Cancer Cell Fates: Integrated Biophysical Mechanisms of Fate Commitment

This paper investigates how genomic mechanisms govern cell fate commitment in cancer by analyzing time-series transcriptomes and proposing a framework based on self-organized criticality and information thermodynamics.

Genomic-Thermodynamic Phase Synchronization: Maxwell's Demon-Like Regulation of Cell Fate Transition

The paper analyzes gene expression dynamics in MCF-7 cells under HRG and EGF stimuli, revealing thermodynamic phase synchronization driven by the critical point (CP) and its role in cell fate transitions.

Self-Organization of Whole Gene Expression through Coordinated Chromatin Structural Transition: Validation of Self-Organized Critical Control of Genome Expression

The paper validates self-organized critical control of genome expression through coordinated chromatin structural transitions in MCF-7 breast-cancer cells using RQA and PCA.

Self-Organized Critical Control of Genome Expression: Novel Scenario on Cell-Fate Decision

The paper demonstrates self-organized critical control of genome expression at the single-cell level and proposes a model for cell-fate decision through critical transitions.

Single-Cell Reprogramming Of Mouse Embryo Development Through A Critical Transition State

The paper identifies a critical transition state in mouse embryo development where genome reprogramming occurs through dynamic interactions of thermodynamic states and self-organized criticality.

Self-Organizing Global Gene Expression Regulated Through Criticality: Mechanism of the Cell-Fate Change

The paper demonstrates that self-organized criticality regulates global gene expression during cell-fate changes, with critical states and perturbations driving dynamic transitions.