Transcriptional and functional consequences of alterations to MEF2C and its topological organization in neuronal models
Kiana Mohajeri, Rachita Yadav, Eva D’haene, Philip M. Boone, Serkan Erdin, Dadi Gao, Mariana Moysés‐Oliveira, Riya Bhavsar, Benjamin Currall, Kathryn O’Keefe, Nicholas D. Burt, Chelsea Lowther, Diane E. Lucente, Monica Salani, Mathew Larson, , Michael E. Talkowski
The paper investigates the effects of MEF2C mutations and chromatin structural variants on transcriptional and functional outcomes in neuronal models, revealing differential impacts based on mutation type and chromatin topology.
The American Journal of Human Genetics · Oct 24, 2022Peer-reviewedGenomics