Direct binding to RPA-coated ssDNA allows recruitment of the ATR activator TopBP1 to sites of DNA damage
Julyana Acevedo, Shan Yan, Matt Michael
This study identifies a direct interaction between TopBP1 and RPA-coated ssDNA, showing how TopBP1 is recruited to DNA damage sites to activate ATR.
bioRxiv · Apr 23, 2016Molecular Biology