Author

Matt Sternke

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1

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Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Doug BarrickiD· 1 shared Justin P. NguyeniD· 1 shared Katherine W. TrippiD· 1 shared Soumya Prakash Behera· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBiophysics

Doug BarrickORCID

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1 paper

Recent·Most cited

Protein stability is determined by single-site bias rather than pairwise covariance

Matt Sternke, Katherine W. Tripp, Soumya Prakash Behera, Justin P. Nguyen, Doug Barrick

The paper designs protein sequences with varying single-site biases and pairwise covariances, finding that single-site biases determine stability while pairwise covariances affect catalytic activity.

Nature Chemical Biology · Jul 10, 2026Peer-reviewedBiophysics