Doug Barrick

The paper designs protein sequences with varying single-site biases and pairwise covariances, finding that single-site biases determine stability while pairwise covariances affect catalytic activity.

This study investigates the role of bivalency in Notch signaling by analyzing the energetic contributions of an intrinsically disordered linker to transcription complex assembly.

This study demonstrates that SHARP, a helicase-driven isothermal amplification method, effectively amplifies repetitive and compositionally extreme DNA sequences that are challenging for conventional PCR.