Loss of TP73 function contributes to amyotrophic lateral sclerosis pathogenesis
Jonathan M. Downie, Summer B. Gibson, Spyridoula Tsetsou, Kristi L. Russell, Matthew D. Keefe, Karla Patricia Figueroa, Mark B. Bromberg, Lewis Charles Murtaugh, Joshua L. Bonkowsky, Stefan M. Pulst, Lynn B. Jorde
The paper identifies TP73 variants as risk factors for ALS through exome sequencing and functional assays in cell lines and zebrafish.
bioRxiv · Feb 11, 2019 · PreprintGenetics