Transient centrosome loss in cultured prostate epithelial cells induces chromosomal instability to produce an oncogenic genotype that correlates with poor clinical outcomes
Jiawen Yang, John M. Ryniawec, Diogo de Oliveira Pessôa, Matthew R. Coope, Daniel W. Buster, Emily Loertscher, Mengdie Wang, Chen Chen, Anne E. Cress, Megha Padi, Gregory C. Rogers
The paper shows that transient centrosome loss in prostate cells causes chromosomal instability, leading to oncogenic changes linked to poor clinical outcomes.
British Journal of Cancer · Jan 7, 2026Peer-reviewedCancer Biology