The phosphoproteomic landscape of the neurological manifestations in tuberous sclerosis complex
Marie Girodengo, Simeon R. Mihaylov, Katarzyna Klonowska, Laura Mantoan Ritter, Helen R. Flynn, Mark J. Skehel, Elias Bou Farhat, Eleonora Aronica, Matthew White, David J. Kwiatkowski, Sila K. Ultanir, Joseph M. Bateman
This study performs phosphoproteomic analysis of TSC brain lesions, finding strong mTORC1 activation and widespread mRNA splicing changes in SEGAs but not tubers.
Acta Neuropathologica · May 20, 2026Peer-reviewedNeuroscience