TDP-43 loss induces extensive cryptic polyadenylation in ALS/FTD
Sam Bryce-Smith, Anna‐Leigh Brown, Puja R. Mehta, Francesca Mattedi, Alla Mikheenko, Simone Barattucci, Matteo Zanovello, Dario Dattilo, Matthew Yome, Sarah E. Kargbo-Hill, Yue Andy Qi, Oscar G. Wilkins, Kai Sun, Eugeni M. Ryadnov, Yixuan Wan, , Pietro Fratta
The paper identifies novel cryptic polyadenylation events induced by TDP-43 loss in ALS/FTD using bioinformatic methods and shows their potential disease relevance and impact on protein translation.
bioRxiv · Jan 22, 2024 · PreprintNeuroscience