Disentangling Brain-Psychopathology Associations: A Systematic Evaluation of Transdiagnostic Latent Factor Models
Martin Gell, Mauricio S Hoffmann, Tyler M. Moore, Aki Nikolaidis, R. C. Gur, Giovanni A. Salum, Michael Peter Milham, Robert Langner, Veronika I. Müller, Simon Bodo Eickhoff, Theodore Daniel Satterthwaite, Brenden Tervo‐Clemmens
This study evaluates transdiagnostic latent factor models for brain-psychopathology associations using neuroimaging data, finding no consistent improvement in predictive utility over summary scores.
bioRxiv · Jun 13, 2026 · PreprintNeuroscience