Ischemia-Induced Post-Translational Modifications of GLT-1 Mediate Aberrant Trafficking and Impaired Glutamate Uptake
Simran K. Gill, Katelyn Louise Reeb, Max Kroll, Ole Valente Mortensen, Andréia C. K. Fontana
This study shows that ischemia-induced ubiquitination of GLT-1 leads to its internalization and reduced glutamate uptake, contributing to neuronal damage, and that disrupting this process can restore function and provide neuroprotection.
Journal of Neurochemistry · Jun 1, 2026Peer-reviewedMolecular Biology