Author

Maximilian G. Plach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:machine learning (classical)· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Florian KaiseriD· 2 shared Thomas E. O. SchubertiD· 2 shared V. Joachim HauptiD· 2 shared Christoph LeberechtiD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersBioinformatics

Florian KaiserORCID

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2 papers

Recent·Most cited

In Silico Driven Prediction of MAPK14 Off-Targets Reveals Unrelated Proteins with High Accuracy

Florian Kaiser, Maximilian G. Plach, Christoph Leberecht, Thomas E. O. Schubert, V. Joachim Haupt

The paper predicts off-targets of a MAPK14 inhibitor using in silico methods and validates them experimentally, achieving a 46% hit rate.

bioRxiv · Jul 24, 2020 · PreprintBioinformatics

Focus Your Screening Library: Rapid Identification of Novel PDE2 Inhibitors with in silico Driven Library Prioritization and MicroScale Thermophoresis

Florian Kaiser, Maximilian G. Plach, Thomas E. O. Schubert, V. Joachim Haupt

The paper uses AI-based drug screening and biophysics to identify novel PDE2 inhibitors from a chemical library, achieving a 6% hit rate with compounds showing micromolar affinities.

bioRxiv · Apr 22, 2020 · PreprintBioinformatics