Competition between binding sites determines gene expression at low transcription factor concentrations
David van Dijk, Eilon Sharon, Maya Lotan-Pompan, Adina Weinberger, Eran Segal, Lucas B. Carey
The paper measures promoter activity in budding yeast under varying TF concentrations and shows that competition between binding sites, not site number, determines gene expression, with a thermodynamic model explaining the results.
bioRxiv · May 5, 2016 · PreprintSystems Biology