The Dynorphin/Kappa Opioid Receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma in male mice
Suhjung Janet Lee, Aric Flint Logsdon, Mayumi Yagi, Britahny M. Baskin, Elaine R. Peskind, Murray M. Raskind, David G. Cook, Abigail G. Schindler
This study shows that repetitive blast trauma in mice increases dynorphin and cytokines, which are reduced by a KOR antagonist, improving behavioral outcomes.
Journal of Neuroinflammation · Dec 3, 2022Peer-reviewedNeuroscience