Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels
Veronica Cherdyntseva, Paulson, Joanna, Daniel González‐Acosta, Patricia Ubieto‐Capella, Melani Rodrigues, Moses Aouami, Selin Adakli, Jean‐Philippe Gagné, Collin Bakker, Guy G. Poirier, Nitika Taneja, Massimo Lopes
This study shows that Lamin A/C modulates replication fork restart under stress by affecting H3K9me3 and PAR levels, impacting chromosome stability and chemotherapy response.
Nature Communications · Nov 29, 2025Peer-reviewedMolecular Biology