Adenosine modulates extracellular glutamate levels via adenosine A2A receptors in the delayed-ethanol induced headache.
Nathan T. Fried, Christina R. Maxwell, Jan B. Hoek, Melanie B. Elliott, Michael L. Oshinsky
This study shows that acetate increases brainstem adenosine and glutamate, contributing to ethanol-induced headache via A2A receptor activation.
bioRxiv · Oct 2, 2020 · PreprintNeuroscience