CopY as a Transcriptional Duet Orchestrating Copper Homeostasis via Asymmetry-Dependent DNA Affinity
Melanie Hirsch, Aparna Liz Benny, Lukas Hofmann, Yulia Shenberger, Lada Gevorkyan‐Airapetov, Sunil Saxena, Sharon Ruthstein
This study investigates how CopY, a bacterial copper regulator, uses two non-equivalent operator sites to repress gene expression through distinct molecular mechanisms.
bioRxiv · Oct 8, 2026 · PreprintBiophysics