Acute silencing uncovers multiple forms of activity-dependent neuronal survival in the mature entorhinal cortex
Rong Zhao, Stacy D. Grunke, Ming-Hua Li, Caleb A. Wood, Gabriella Perez, Melissa Comstock, Anand Kumar Singh, Kyung-Won Park, Joanna L. Jankowsky
The paper investigates activity-dependent neuronal survival in the adult entorhinal cortex and finds that electrical activity and synaptic transmission are both required for neuronal survival, with distinct degeneration mechanisms triggered by different silencing methods.
eLife · Dec 5, 2022Peer-reviewedNeuroscience