Genome-wide analysis of genetic risk factors for rheumatic heart disease in Aboriginal Australians provides support for pathogenic molecular mimicry
Lesley-Ann Gray, Heather A D’Antoine, Steven Y. C. Tong, Melita McKinnon, Dawn C Bessarab, Ngiare J Brown, Bo Reményi, Andrew C. Steer, Genevieve Syn, Jenefer Mary Blackwell, Michael Inouye, Jonathan Rhys Carapetis
This study identifies HLA-DQA1-DQB1 variants as genetic risk factors for rheumatic heart disease in Aboriginal Australians, supporting molecular mimicry as a pathogenic mechanism.
The Journal of Infectious Diseases · Sep 20, 2017Peer-reviewedGenetics