A hierarchical activation threshold shapes RSV F antibody repertoires from toddler vulnerability to adult protection
Jie Deng, Yixin Li, Siyu Lei, Kaijun Xu, Jianhui Nie, Hui Zhai, Jinyue Wang, Lingjie Xu, Fanchong Jian, Rui Feng, Zhe Lv, WenXiang Yu, Mengyang Ma, Yuxia Zhang, Chun Zhang, , Xiangxi Wang
This study identifies a hierarchical activation threshold in RSV F antibody repertoires, explaining pediatric vulnerability and adult protection through distinct antibody subclasses and epitope targeting.
bioRxiv · Jul 29, 2026 · PreprintImmunology