Author

Siyu Lei

Peking University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Fanchong JianiD· 2 shared Yunlong CaoiD· 2 shared Chun ZhangiD· 1 shared Enmei LiuiD· 1 shared Fei Shao· 1 shared Haiyan SuniD· 1 shared Hui ZhaiiD· 1 shared Jianhui NieiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

Fanchong JianORCID

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Author profile →

2 papers

Recent·Most cited

A hierarchical activation threshold shapes RSV F antibody repertoires from toddler vulnerability to adult protection

Jie Deng, Yixin Li, Siyu Lei, Kaijun Xu, Jianhui Nie, Hui Zhai, Jinyue Wang, Lingjie Xu, Fanchong Jian, Rui Feng, Zhe Lv, WenXiang Yu, Mengyang Ma, Yuxia Zhang, Chun Zhang, , Xiangxi Wang

This study identifies a hierarchical activation threshold in RSV F antibody repertoires, explaining pediatric vulnerability and adult protection through distinct antibody subclasses and epitope targeting.

bioRxiv · Jul 29, 2026 · PreprintImmunology

Mouse V(D)J Humanization Recapitulates human-like Severe SARS-CoV-2 Immune Imprinting

Xiao Niu, Fanchong Jian, Yutong Kelly Li, Ke Li, Siyu Lei, Weiliang Song, Rui Kong, X L Cai, Ran An, Yao Wang, Yifei Huang, Lingling Yu, Wenjing Wang, Haiyan Sun, Yuanling Yu, , Yunlong Cao

This study shows that V(D)J-humanized mice can replicate severe SARS-CoV-2 immune imprinting in humans, revealing that pre-existing antibody abundance influences imprinting severity.

bioRxiv · Jun 11, 2026 · PreprintImmunology