Bi-phasic regulation of AIMP2 and its splice variant in PARP-1- dependent neurodegeneration
Min Hak Lee, Mi Ran Byun, Seok Won Lee, Eui Jin Lee, Young Ok Jo, Sung Hyun Kim, Wongi Seol, Kyunghwa Baek, Jin Woo Choi
This study identifies DX2, an AIMP2 splice variant that inhibits PARP-1 and alleviates Parkinson's disease symptoms in animal models.
bioRxiv · Apr 6, 2022 · PreprintMolecular Biology