Sung Hyun Kim

AUTOTAC-mediated targeted degradation of transthyretin aggregates ameliorates hereditary transthyretin amyloidosis

This study identifies the N-degron pathway's role in lysosomal degradation of TTRV30M aggregates and demonstrates the therapeutic potential of AUTOTAC-based degraders for hATTR.

Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform

This paper develops AUTOTAC degraders to target and degrade pathogenic TDP-43 aggregates in ALS, showing efficacy in mice and entering clinical trials.

L-type Ca2+ channels mediate regulation of glutamate release by subthreshold potential changes

This study investigates how subthreshold depolarization enhances glutamate release via L-type Ca2+ channels and Ca2+-dependent signaling molecules.

Bi-phasic regulation of AIMP2 and its splice variant in PARP-1- dependent neurodegeneration

This study identifies DX2, an AIMP2 splice variant that inhibits PARP-1 and alleviates Parkinson's disease symptoms in animal models.