Disulphide and sequence-encoded conformational priors guide nanobody structure prediction
Montader Ali, Mateusz Jaskółowski, Matthew Greenig, Tung H. Nguyen, Mia Crnogaj, Eva Smorodina, Aubin Ramon, Haowen Zhao, Monica L. Fernández‐Quintero, Elodie Ghedin, Victor Greiff, Pietro Sormanni
This paper introduces NbForge, a nanobody folding model that improves prediction of HCDR3 blueprint and disulphide bonds, achieving accuracy comparable to large predictors with faster speed.
bioRxiv · Feb 13, 2026 · PreprintBioinformatics