Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy
Alexander Martin Rossor, James N. Sleigh, Michael Groves, Francesco Muntoni A, Mary M. Reilly, Casper C. Hoogenraad, Giampietro Schiavo
This study shows that loss of BICD2 in muscle drives motor neuron loss in SMALED2 through a non-cell autonomous mechanism involving impaired secretory pathways.
Acta Neuropathologica Communications · Mar 17, 2020Peer-reviewedNeuroscience