Modeling bi-modality improves characterization of cell cycle on gene expression in single cells
Lucas Dennis, Andrew McDavid, Patrick Danaher, Greg Finak, Michael Krouse, Alice Wang, Philippa Webster, Joseph Beechem, Raphael Gottardo
The paper models bi-modality in single-cell gene expression to improve characterization of cell cycle effects and finds the cell cycle explains 5%-17% of expression variability.
PLoS Computational Biology · Jul 17, 2014Peer-reviewedBioinformatics