Neurodegeneration Associated with Repeated High-Frequency Transcranial Focused Ultrasound
Andrew Brna, Oleg V. Favorov, Timothy Challener, Ali Önder Biliroğlu, Feysel Yalcin Yamaner, Remzi Erkan Kemal, Muhammetgeldi Annayev, Ömer Oralkan, Derek M. Eidum, Stephen B. Simons, Michael P. Weisend, Patrick M. Connolly
This study shows that repeated high-frequency tFUS exposure in non-human primates leads to neurodegeneration in stimulated and functionally connected brain regions, despite no behavioral disruption.
bioRxiv · Sep 23, 2025 · PreprintNeuroscience