Re-evaluating the Need for Double Centrifugation in Plasma Cell-Free DNA Analysis
Y Wang, Patricia Ann Shaw, Amanda Vallon, Lucas Tavares Naief, Austin R Hicks, Michaela Ednie, Laken Ritzert, FRG Amrit, Tianjiao Chu, Chris G. McKennan, David Gerard Peters
This study shows that single-spun plasma is sufficient for accurate cfDNA analysis, challenging the need for double centrifugation in liquid biopsy workflows.
bioRxiv · Feb 2, 2026 · PreprintGenomics