Dihydropyrimidines sustain aggressive cancer states by stabilizing DPYSL2
Arata Hayashi, Sarah Knapp, Abdelrahaman Karmi, Vaibhav Gupta, Itai Mizrahi, Shirel Lavi, Sinai Shammah, Yael Sitton, Ravit Glukhman, Balakrishnan Solaimuthu, Sayanika Banerjee, Areej Abu Rmaileh, Anees Khatib, Michal Lichtenstein, Ora Schueler‐Furman, , Yoav David Shaul
This study identifies dihydropyrimidines (DHPs) as signaling metabolites that sustain aggressive cancer states by stabilizing DPYSL2, linking metabolic activity to oncogenic signaling.
bioRxiv · Jun 18, 2026 · PreprintCancer Biology