PAX fusion proteins deregulate gene networks controlling mitochondrial translation in pediatric rhabdomyosarcoma
Bhargab Kalita, Gerard Martínez-Cebrián, Justina D. McEvoy, Melody Lyn Allensworth, Michelle Knight, Alessandro Magli, Rita C. R. Perlingeiro, Michael A. Dyer, Elizabeth A. Stewart, Brian David Dynlacht
This study identifies PAX3-FOXO1 and PAX7-FOXO1 fusion proteins as drivers of mitochondrial translation gene networks in pediatric rhabdomyosarcoma, offering new therapeutic targets.
Cell · Aug 3, 2024Peer-reviewedCancer Biology