Leveraging epigenetic vulnerabilities of the stem cell-related HOX-signature in glioblastoma
Davide Chiesi, Pierre Bady, Mihalis Xirouchakis, Carla Susana Mendes Ferreira, Kedir Seid Mohammed, Monika E. Hegi
This study identifies epigenetic vulnerabilities in high-HOX glioblastoma by showing that BETi or HOXA10 knockdown represses the HOX-signature and reduces stemness features.
bioRxiv · May 29, 2026 · PreprintCancer Biology