Author

Mingshu Zhang

Peking University

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Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:optimal transport· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Bin He· 1 shared Bin Li· 1 shared Haicang ZhangiD· 1 shared Jian ZhangiD· 1 shared Yuliang Fan· 1 shared Zaikai He· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperBioinformatics

Bin He

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1 paper

Recent·Most cited

PocketX: Preference Alignment for Protein Pockets Design through Group Relative Policy Optimization

Yuliang Fan, Zaikai He, Bin Li, Bin He, Mingshu Zhang, Jian Zhang, Haicang Zhang

PocketX uses reinforcement learning to align protein pocket design with biophysical properties, outperforming existing methods on binding energy and evolutionary plausibility.

bioRxiv · Dec 28, 2025 · PreprintBioinformatics