Improved Prediction of Bacterial Type VI Secretion Effector Proteins Using an Integrated Convolutional Neural Network Model Combining N-terminal Signal Sequences, Evolutionary Information and Pre-Trained Protein Language Features
Yueming Hu, Minqing Yan, Yanyan Zhu, Haoyu Chao, Sida Li, Qinyang Ni, Yanshi Hu, Enyan Liu, Liya Liu, Yifan Chen, Zeya Zhou, Yuhao Chen, Shilong Zhang, Yejun Wang, Cong Feng, Ming Chen
This paper introduces T6CNN, a model that improves T6SE prediction by integrating signal sequences, evolutionary data, and pre-trained features, achieving higher accuracy, sensitivity, and specificity than existing tools.
bioRxiv · Mar 7, 2025 · PreprintBioinformatics