Effect of a Dietary Intervention on Weight Loss in Adults with High vs Low Genetic Predisposition to Higher BMI: A Randomized Diet Intervention Trial
Rodosthenis S. Rodosthenous, Leena E. Viiri, Anne Carson, Tatiana Cajuso, Andrea Corbetta, Samuel E. Jones, Ettore Brenna, FinnGen, Enni Makkonen, Minttu Virolainen, Niina Korkeala, Elisabeth Widén, Samuli Ripatti, Andrea Ganna
This study evaluates if weight loss from a dietary intervention varies by genetic predisposition to higher BMI, finding no significant interaction between polygenic scores and intervention effectiveness.
medRxiv · Oct 6, 2025 · PreprintGenetic & Genomic Medicine