Elisabeth Widén

Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects

The paper conducts a multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycemic traits, identifying novel loci and highlighting limited pregnancy-specific genetic effects.

Effect of a Dietary Intervention on Weight Loss in Adults with High vs Low Genetic Predisposition to Higher BMI: A Randomized Diet Intervention Trial

This study evaluates if weight loss from a dietary intervention varies by genetic predisposition to higher BMI, finding no significant interaction between polygenic scores and intervention effectiveness.

Inherited infertility- mapping loci associated with impaired female reproduction

The paper identifies genetic loci associated with female infertility through a GWAS, revealing a rare recessive mutation in TBPL2 and age-dependent risk factors.

Genome-wide association analysis of plasma lipidome identifies 495 genetic associations

This study identifies 495 genetic associations with plasma lipid species using genome-wide analysis in 7,174 Finnish individuals and fine-mapping in 377,277 participants, revealing 9 novel loci and disease links.

A FinnGen pilot clinical recall study for Alzheimer's disease

The paper demonstrates the feasibility of conducting clinical recall studies from the FinnGen biobank to collect customized clinical data from participants with Alzheimer's disease or mild cognitive disorder.

Systematic comparison of family history and polygenic risk across 24 common diseases

This study compares family history and polygenic risk scores across 24 diseases, showing they provide complementary rather than interchangeable information about inherited disease risk.

Lipidome- and genome-wide study to understand sex differences in circulatory lipids

The paper examines sex differences in circulatory lipids and their genetic determinants using lipidomics and genome-wide association studies across multiple cohorts.

Communicating polygenic and non-genetic risk for atherosclerotic cardiovascular disease - An observational follow-up study

This study evaluates the impact of communicating polygenic and clinical risk scores for ASCVD via a web tool, finding that high-risk individuals made more health behavior changes.

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

This GWAS identifies 123 migraine risk loci, including subtype-specific variants and novel targets, supporting neurovascular mechanisms in migraine.

Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health

The paper integrates multiomics and digital health data from 96 individuals over 16 months to identify independent molecular factors linked to health outcomes and lifestyle changes.

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

This paper identifies potential nootropic drug targets by integrating large-scale cognitive GWAS and transcriptomic data to find credible druggable genes.

Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers

The paper evaluates polygenic risk scores and clinical risk factors for predicting early-onset cardiometabolic diseases and cancers, showing comparable performance to clinical scores.

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

The paper uses pleiotropic meta-analysis to identify genetic loci associated with cognition, education, and schizophrenia, revealing distinct biological mechanisms for concordant and discordant genetic correlations.

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

This study performs a large-scale GWAS of cognitive ability, identifies 70 genomic loci, and finds tissue-specific gene expression and potential drug targets.

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

This study identifies genetic loci associated with early childhood growth phenotypes and links them to later adiposity traits, suggesting potential targets for obesity prevention.