Quantification of X-chromosome inactivation in fibroblast and iPSC models of UBQLN2 ALS/FTD using allele-selective qPCR
David C. Gordon, Kyrah M. Thumbadoo, Serey Naidoo, Agnes L. Nishimura, Miriam Rodrigues, Harry G. Fraser, Anthony N. Cutrupi, Richard H Roxburgh, Christopher E. Shaw, Marina L. Kennerson, Emma L. Scotter
The paper develops an allele-selective qPCR assay to quantify X-chromosome inactivation in iPSC models of UBQLN2 ALS/FTD and identifies clones retaining XCI for further study.
bioRxiv · Aug 20, 2026 · PreprintMolecular Biology