ISRIB promotes aggregation of TIA-1 by modulating its phase separation in vitro
Miyu Murata, Hitomi Kimura, Shin-ichi Tate, Kyota Yasuda
This study shows ISRIB enhances TIA-1 phase separation and promotes its aggregation in vitro, with RNA mitigating this effect.
bioRxiv · Jul 7, 2025 · PreprintMolecular Biology