CDKs-mediated phosphorylation of PNKP is required for end processing of single-strand DNA gaps on Okazaki Fragments and genome stability
Kaima Tsukada, Rikiya Imamura, Tomoko Miyake, Kotaro Saikawa, Mizuki Saito, Naoya Kase, Lingyan Fu, Masamichi Ishiai, Yoshihisa Matsumoto, Mikio Shimada
This study shows CDK-mediated phosphorylation of PNKP at T118 is essential for its recruitment to single-strand DNA gaps during Okazaki fragment ligation and genome stability.
eLife · Mar 12, 2025Peer-reviewedMolecular Biology