Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease.
Andrea D. Olivas, Patricia Ngai, Emily Schahrer, Junjie Xing, Mobarakeh Ghadiri, Kinga S. Olortegui, John Cursio, Shintaro Akiyama, Eugene B. Chang, Le Shen, Konstantin Umanskiy, David T. Rubin, David Zemmour, Christopher R. Weber
This study identifies histopathological and molecular features linked to J-pouch failure in IBD patients using single-cell spatial transcriptomics.
Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2025Peer-reviewedPathology