Christopher R. Weber

An engineered Clostridial mini consortium modulates intestinal inflammation

The paper engineers a Clostridial consortium to study isoDCA's role in modulating intestinal inflammation and regulatory T cell induction.

Cryo-electron tomography reveals paracellular claudin-15 pores at the tight junction

The paper uses cryo-electron tomography to directly visualize paracellular claudin-15 pores in tight junctions, confirming their structure and spacing.

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

This study shows that pancreatic cancer cells in a nutrient-stressed tumor microenvironment develop drug tolerance, and identifies BCL-XL inhibition as a potential therapeutic strategy.

Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease.

This study identifies histopathological and molecular features linked to J-pouch failure in IBD patients using single-cell spatial transcriptomics.

ATAT: Automated Tissue Alignment and Traversal in Spatial Transcriptomics with Self-Supervised Learning

ATAT automates spatial transcriptomics analysis by aligning and traversing tissue samples using self-supervised learning, improving gene expression modeling without manual annotation.