Structural determinants of pure antiestrogenicity
Marine Diennet, F. Shaikh, Mohamed El Ezzy, Khady Thiombane, Sandra Weber, Julien Poupart, Rodrigo Mendoza‐Sanchez, Zu‐Hua Gao, James L. Gleason, Doris A. Schuetz, Geoffrey L. Greene, Anne Marinier, Sean William Fanning, Sylvie Mader
This study identifies structural determinants of antiestrogenicity by showing that ER SUMOylation, influenced by N-terminal hydrophobicity, mediates complete transcriptional repression.
bioRxiv · Oct 31, 2023 · PreprintMolecular Biology