Author

Sylvie Mader

Institute for Research in Immunology and CancerORCID 0000-0002-6423-627XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:CRISPR screen· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Andrew Chatr‐aryamontriiD· 2 shared Anne MarinieriD· 2 shared Brian T. WilhelmiD· 2 shared Ivan TopisirovićiD· 2 shared Li ZhangiD· 2 shared Mike TyersiD· 2 shared Philippe P. RouxiD· 2 shared Thierry BertomeuiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersSystems Biology

Andrew Chatr‐aryamontriORCID

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Author profile →

4 papers

Recent·Most cited

Systems BiologybioRxivPreprintJan 30, 2026

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture

Jasmin Coulombe‐Huntington, Thierry Bertomeu, Caroline Huard…·Mike Tyers

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

1 citation

humanCRISPR screen

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Cancer BiologybioRxivPreprintSep 4, 2025

EZH2 Inhibition Induces a Metabolic Stress Response Sensitizing TNBC to Glutaminase Targeting

Lucas Porras, Marina Fukano, Ann-Sophie Gironne…·Geneviève Deblois

This study shows that EZH2 inhibition in TNBC causes metabolic stress, making cells more sensitive to glutaminase inhibitors.

DOI 10.1101/2025.09.04.674332

humanproteomics

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GeneticsbioRxivPreprintAug 4, 2025

A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of concept

Andrew Chatr‐aryamontri, Li Zhang, Ndeye Khady Thiombane…·Thierry Bertomeu

The paper introduces a method for systematically studying genetic interactions in human cells using CRISPR/Cas9 screens and demonstrates its effectiveness through 26 gene by genome-wide knockout screens.

DOI 10.1101/2025.08.04.665369

humanCRISPR screen

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Molecular BiologybioRxivPreprintOct 31, 2023

Structural determinants of pure antiestrogenicity

Marine Diennet, F. Shaikh, Mohamed El Ezzy…·Sylvie Mader

This study identifies structural determinants of antiestrogenicity by showing that ER SUMOylation, influenced by N-terminal hydrophobicity, mediates complete transcriptional repression.

1 citation

humanprotein structure

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