Dynamic Modeling of Signal Transduction by mTOR Complexes in Cancer
Mohammadreza Dorvash, Mohammad Farahmandnia, Pouria Mosaddeghi, Mitra Farahmandnejad, Hosein Saber, Mohammadhossein Khorraminejad‐Shirazi, Amir Azadi, Iman Tavassoly
The paper develops a mathematical model to explain how rapamycin differentially inhibits mTORC1 and mTORC2 based on Le Chatelier's principle.
Journal of Theoretical Biology · Sep 4, 2019Peer-reviewedSystems Biology