Post-mortem AT-8 reactive tau species correlate with non-plaque Aβ levels in the frontal cortex of non-AD and AD brains
Nauman Malik, Mohi-Uddin Miah, Alessandro Galgani, Kirsty E. McAleese, Lauren Walker, Fiona E. N. LeBeau, Johannes Attems, Tiago F. Outeiro, Alan J. Thomas, David J. Koss
This study shows that intracellular Aβ correlates with AT-8 phosphorylated tau in frontal cortex tissue from non-AD and AD brains, supporting the revised amyloid cascade hypothesis.
bioRxiv · Sep 27, 2023 · PreprintNeuroscience