Johannes Attems

The paper establishes international consensus criteria to classify ageing-related pathologies, diseases, and syndromes based on age progression, functional decline, and human evidence.

This study examines alpha-synuclein pathology in metachromatic leukodystrophy (MLD) brain tissue, finding seed-competent alpha-synuclein conformers in juvenile-onset cases, similar to Lewy body diseases.

This study shows DNA damage and repair dysfunction are linked to alpha-synuclein pathology in dementia with Lewy bodies, with DNA damage-derived material found within Lewy bodies.

This study shows that intracellular Aβ correlates with AT-8 phosphorylated tau in frontal cortex tissue from non-AD and AD brains, supporting the revised amyloid cascade hypothesis.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.