ISGylation Mechanism Uncovers Conformational Specificity for HECT-family E3 ligase
Pritiranjan Sahoo, Gloria Grace Parmar, Dipti Ranjan Lenka, Mohini Sherawat, Bhagya Shri Trivedi, Atul Kumar
The paper reveals the conformational specificity of UbcH8[~]ISG15 for HECT-family E3 ligases, explaining its exclusive ISGylation activity and distinct mechanism from ubiquitination.
bioRxiv · Sep 26, 2025 · PreprintBiophysics