Phosphorylation of spleen tyrosine kinase Y130 positively regulates intracellular signaling and functional responses in platelets
Manal Elzoheiry, Carol Dangelmaier, Dhruv N Vajipayajula, Monica N. Wright, Peter J. P. Coopman, Alexander Y. Tsygankov, Satya P. Kunapuli
This study shows that phosphorylation of Syk Y130 enhances GPVI- and CLEC-2-mediated signaling and functional responses in platelets, affecting thrombosis and hemostasis.
bioRxiv · Sep 2, 2026 · PreprintMolecular Biology