Comparing Lipinskis Rule of 5 and Machine Learning Based Prediction of Fraction Absorbed for Assessing Oral Absorption in Humans
Urban Fagerholm, Sven Hellberg, Jonathan Alvarsson, Morgan Ekmefjord, Ola Spjuth
This paper compares Lipinski's Rule of 5 and machine learning predictions of fraction absorbed to assess oral absorption in humans, finding machine learning models more accurate.
bioRxiv · Aug 20, 2024 · PreprintPharmacology & Toxicology