Molecular Plasticity of T Cells Informs Their Possible Adaptation in 4T1 Tumors
Md. Iftehimul, Robert Howard Newman, Scott Henry Harrison, Roshonda B. Jones, Perpetua M. Muganda, Bryan Latrell Holloman, Muhammad T. Hossain, Checo J. Rorie, Misty D. Thomas, Joseph L. Graves, Howard L. Kaufman, Dipongkor Saha
This study tracks T cell transcriptional changes in 4T1 tumors over time, revealing functional decline, reduced TCR diversity, and immunosuppressive shifts in the tumor microenvironment.
bioRxiv · Oct 17, 2025 · PreprintCancer Biology