Genome-wide transcription factor activities are explained by intrinsic conformational dynamics of binding-sites and distal flanking-regions
Munazah Andrabi, Andrew Paul Hutchins, Diego Miranda-Saavedra, Hidetoshi Kono, Ruth Nussinov, Kenji Mizuguchi, Shandar Ahmad
This study introduces DynaSeq, a method that uses DNA conformational dynamics to predict TF binding patterns and explains how these dynamics influence TF specificity in STAT3 and chromatin structural classes.
bioRxiv · Jun 9, 2015 · PreprintGenomics